Activation of cannabinoid receptors by endocannabinoids on epidermal cells regulates normal function of the skin as a barrier. When CB1 or CB2 are engaged, these functions of epidermal cells are modified – whether through proliferation, differentiation or apoptosis – which are all important processes for the healthy physical defense of the body. Endocannabinoids also suppress inflammation in the epidermis.
Cannabinoid receptor modulation controls the symptoms of nausea and vomiting. When cannabinoid receptor CB1 is stimulate, vomiting is suppressed.
Endocannabinoids promote non-rapid-eye movement and rapid-eye-movement sleep by interacting with melanin-concentrating hormone neurons in the lateral hypothalamus.
Chronic pain is also the most common reason for using cannabinoids. The endocannabinoid system uses the degredation of two main enzymes to treat pain, anandamide and a2-Arachidonoylglycerol (2-AG). The breakdown of these enzymes in the presynaptic and postsynaptic neuron allow for inhibition and reduction of neuropathic pain symptoms.
By boosting our body’s serotonin receptors and increasing its communication, CBD provides great option for treating all anxieties. CBD also works in a much faster manner than current medical antidepressant therapies, solving some of its medical limitations.